Home Innovation Innovative Small Molecule(s) Research Institute

Small molecule drugs are biologically active compounds synthesized with organic chemistry approaches, with molecular weight below 1000 Da. They have excellent pharmacological functions and tissue distribution properties, allowing for broad therapeutic indications. They also have good pharmacokinetic profiles and chemical stability, with the advantages of convenient storage and transportation. They are orally administered; hence it is easier to get patients to comply with treatments. Furthermore, they can be designed in novel and creative ways for differentiation and unmet medical needs. For these reasons, small molecules exert huge therapeutic potential in various disease areas and continue to be the mainstay of the pharmaceutical industry.

R & D Overview

Focusing on current urgent and unmet medical needs, the Innovative Small Molecules Research Institute are committed to developing new small molecule therapeutics. We aim for comprehensive understandings of the disease biology and establishment of innovative, high-value portfolio. 

Our pipeline covers 5 major disease areas, including kidney diseases, oncology, respiratory and infectious diseases, and neurological disorders. Our team of scientists bring together deep expertise in discovery biology, medicinal chemistry, pharmacology, ADME, toxicology, formulation and process development, regulatory affairs and clinical development. We combine our unique knowledge and experiences with cutting-edge technologies including chemo-informatics, molecular biology, computer-assisted drug design, artificial intelligence and machine learning, to gain speed and improve success rates of small molecule screening and optimization.

Mechanism of Drug Action

Ongoing Projects

Pipeline S/N Product number Product introduction
1 JMKX000189 Renal disease (SLE), with significant in vivo efficacy and less side effects
2 JMKX003002 A new generation of drug, capable of improving patient compliance by oral administration with less dosage
3 JMKX003142 With lower liver toxicity and CYP inhibition, potential to be the BIC drug
4 JMKX003561 Indication of renal disease (chronic fibrosis)
5 JMB2003 Treat renal disease with multiple indications
Oncology 6 JMKX000197 Novel mechanism of action FIC drug, and also develop as FI (first indication) drug
7 JMKX001899 Treatment of non-small cell lung cancer and colorectal carcinoma, featured as good brain penetration, high activity, and high tumor tissue distribution
8 JMKX002992 Treatment of prostatic carcinoma, based on PROTAC technology and degrades broad spectrum of mutated ARs with potential of BIC drug
9 JMKX003948 Treatment of renal carcinoma and glioma, can inhibit multiple tumor-related growth factors
Respiratory Diseases 10 JMKX003561 Treatment of pneumopathy (pulmonary fibrosis)
11 JMKX003676 For fungal infection treatment, BIC drug with high activity and low hepatotoxicity
12 JMKX003801 For bacterial infection treatment, BIC drug against multiple drug-resistant bacteria
Pain 13 JMKX000189 Protection of brain cells and blood vessels after stroke attack
14 JMKX000623 treatment of postoperative, inflammation and neuralgia analgesia
15 JMKX001149 Prevention and treatment of myocardial infarction and cerebral infarction with benefits of reducing the risk of hemorrhage
16 JMN-2204 FIC drug, neuroprotection after stroke attack
17 JMN-2103 FIC drug, treatment of heart failure

R & D Team

51% scientists with MS degrees
23% scientists with PhD degrees

The Innovative Small Molecules Research Institute has a team of 150 scientists, of whom 23% hold PhD degree and 51% hold MS degrees. The management team are seasoned scientists trained overseas with rich experience from leading pharmaceutical companies worldwide. They have accumulated broad and deep knowledge via leading multiple high-profile programs in the past.

Featured Therapeutic Areas

Cardiovascular Diseases

  • 290 million

    patients with CVD in China

  • over 40% deaths
    of diseased population
  • 1st

    mortality rate

The prevalence and mortality rate of cardiovascular diseases continue to increase in China. It is now the leading cause of deaths, with over 40% deaths of diseased population. The orally delivered small molecule anti-coagulants are widely used in cardiovascular diseases, including stroke, transient ischemic attack, deep venous thrombosis, pulmonary embolism, and myocardial infarction. These drugs significantly inhibit the progression of arterial or venous thrombosis, thereby preventing venous thrombosis. They also prevent stroke and systemic embolism caused by nonvalvular atrial fibrillation, avoiding adverse consequences of acute myocardial infarction.
  • Oncology

    4 million

    new cancer cases very year in China

    Malignant tumor has been a major threat. Currently around 4 million new cases are reported every year in China.
    The small molecule anti-tumor drugs are developed against oncogenes. Once absorbed, these drugs specifically bind to their targets, leading to the apoptosis induction and proliferation inhibition of tumor cells. Targeted drugs show much higher specificity, better efficacy, and less toxicity, as compared to conventional chemotherapeutic agents.

  • Kidney Diseases

    119.5 million

    CKD patients in China

    The chronic kidney disease (CKD) is a common chronic disease in China, and current patient population is about 119.5 million. The progression of CKD is affected by multiple factors, including hemodynamic changes, metabolic disorders, inflammation, and fibrosis. In addition to existing prophylactic approaches of lowering blood pressure (controlling hemodynamics) and blood sugar (improving metabolism), further novel effective therapeutics are needed to slow down CKD progression. We are working towards this goal by developing small molecule drugs to inhibit hyperactivation of mineralocorticoid receptors and overexpression of inflammatory factors and cytokines, to ultimately reduce inflammation and fibrosis

  • Respiratory and Infectious Diseases

    0.7 million

    deaths due to antibiotic resistance every year worldwide

    The small molecule anti-bacterial drugs interfere with the metabolism of pathogenic microorganisms, inhibiting critical synthetic pathways for nucleic acids, proteins, cell membranes and cell wall. As compared to conventional anti-bacterial agents, the novel molecules we’ve developed are specifically designed to tackle multidrug resistance. They showed broader spectrum, higher bactericidal activity, and better safety profile in human. These molecules are effective against several multidrug resistant (MDR) bacteria, providing a potentially better option for treating MDR bacterial infections and severe systemic infections.